2-nitro-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole → 1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-ylamine

HRID 43061Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 43061
[N+:1]([C:4]1[N:5]([CH2:9][O:10][CH2:11][CH2:12][Si:13]([CH3:16])([CH3:15])[CH3:14])[CH:6]=[CH:7][N:8]=1)([O-])=O>[Pd].CO>[CH3:14][Si:13]([CH3:16])([CH3:15])[CH2:12][CH2:11][O:10][CH2:9][N:5]1[CH:6]=[CH:7][N:8]=[C:4]1[NH2:1]

Komponenten

4

Edukt 1

HCID 143583852-nitro-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole

Produkt 1

HCID 669145481-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-ylamineAusbeute 96 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A suspension of 2-nitro-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole (Step 14.3) (1.84 g, 7.57 mmol) and palladium on carbon (200 mg) in MeOH (30 mL) was stirred for 40 min at rt, under a hydrogen atmosphere. The reaction mixture was filtered through a pad of celite and concentrated to afford 1.55 g of the title compound: ESI-MS: 214.1 [M+H]+; tR=3.26 min (System 1).

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through a pad of celite
  2. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-1c4ad95aea094add9567a8356d391640
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08536175B2

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