Hydrochloric Acid → HCID 4738324, Verbindung

HRID 430767Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 430767
[CH3:1][O:2][C:3]1[C:11]2[O:10][CH:9]=[C:8]([CH2:12][C:13]([O:15]C)=[O:14])[C:7]=2[CH:6]=[CH:5][CH:4]=1.[OH-].[Na+].Cl.O>CO>[CH3:1][O:2][C:3]1[C:11]2[O:10][CH:9]=[C:8]([CH2:12][C:13]([OH:15])=[O:14])[C:7]=2[CH:6]=[CH:5][CH:4]=1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 11435946Methyl 2-(7-methoxybenzofuran-3-yl)acetate

Produkt 1

HCID 4738324HCID 4738324, VerbindungAusbeute 91 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Methyl (7-methoxy-benzofuran-3-yl)acetate (1.12 g) was dissolved in methanol (20 ml). To this solution, 2N aqueous sodium hydroxide solution (5 ml) was added and the resulting solution was stirred at room temperature for 13.5 hours. To this solution, 1N hydrochloric acid (12 ml) was added and the reaction solution was poured into water layer (200 ml), followed by extraction twice with ethyl acetate (50 ml). The organic layers were combined and washed with saturated brine, followed by drying over sodium sulfate. Sodium sulfate was removed by filtration and the solvent was removed under reduced pressure. The residue was recrystallized from hexane/chloroform to obtain the desired compound (0.95 g, yield: 91%).

Aufarbeitung

  1. extractionfollowed by extraction twice with ethyl acetate (50 ml)
  2. washwashed with saturated brine
  3. dry with materialby drying over sodium sulfate
  4. customSodium sulfate was removed by filtration
  5. customthe solvent was removed under reduced pressure
  6. customThe residue was recrystallized from hexane/chloroform

Quellen und Nachweise

ORD-Eintrag
ord-3c297ee405ad4169931342fe959e72b3
Quelldatensatz
uspto-grants-2001_11
Patentnummer
US06323235B1

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