Hydrogen Bromide → 3-Bromopiperidine-2,6-dione

HRID 430954

Reaktionsgleichung

Reaktionsgleichung von HRID 430954
[Br:1]Br.[C:3]1(=[O:10])[NH:8][C:7](=[O:9])[CH2:6][CH2:5][CH2:4]1.Br>C(Cl)(Cl)Cl>[Br:1][CH:4]1[CH2:5][CH2:6][C:7](=[O:9])[NH:8][C:3]1=[O:10]

Komponenten

5

Edukt 3

HCID 260Hydrogen BromideHCID 24408BromineHCID 70726Glutarimide

Produkt 1

HCID 125707753-Bromopiperidine-2,6-dione

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Reaktionsbedingungen

Temperatur
110 °C

Versuchsvorschrift

4.5 ml bromine were added to 10.2 g glutarimide suspended in 20 ml chloroform and the mixture was stirred in a closed vessel for 90 minutes at a bath temperature of 110° C. After cooling, the vessel was opened and stirring was continued until no more hydrogen bromide escaped. The reaction mixture was evaporated in vacuo, the residue dissolved in ethanol and evaporated again. 17.1 g (99% of theoretical) of the title compound remained in the form of practically white crystals, which melted at 76 to 83° C.

Aufarbeitung

  1. temperatureAfter cooling
  2. stirringstirring
  3. customThe reaction mixture was evaporated in vacuo
  4. dissolutionthe residue dissolved in ethanol
  5. customevaporated again

Quellen und Nachweise

ORD-Eintrag
ord-e08265c7b9ea453a829702908d998a35
Quelldatensatz
uspto-grants-2003_12
Patentnummer
US06656937B2

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