Tert-butyl 2-(2-azidoethoxy)ethyl(methyl)carbamate → tert-butyl N-(2-(2-aminoethoxy)ethyl)-N-methylcarbamate
Reaktionsgleichung
[N:1]([CH2:4][CH2:5][O:6][CH2:7][CH2:8][N:9]([CH3:17])[C:10](=[O:16])[O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[N+]=[N-]>CO.[Pd]>[NH2:1][CH2:4][CH2:5][O:6][CH2:7][CH2:8][N:9]([CH3:17])[C:10](=[O:16])[O:11][C:12]([CH3:13])([CH3:14])[CH3:15]Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
A solution tert-butyl 2-(2-azidoethoxy)ethyl(methyl)carbamate (41.9 g, 170 mmol) in 600 mL of MeOH was treated with 2.5 g of 10% Pd on carbon and shaken under H2 (3 Kg/cm2) for 24 h. The solution was then filtered through a Celite pad and concentrated to give 37.2 g of crude tert-butyl 2-(2-aminoethoxy)ethyl(methyl)carbamate as a light yellow liquid.
Aufarbeitung
- filtrationThe solution was then filtered through a Celite pad
- concentrationconcentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-c83ec4d1067f4ddbb1c3232b71fae6f4
- Quelldatensatz
- uspto-grants-2003_12
- Patentnummer
- US06656938B2
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