1-Butanol → n-Butyl 1-benzoyl-3-piperidinecarboxylate

HRID 432799

Reaktionsgleichung

Reaktionsgleichung von HRID 432799
S1[CH:5]=[CH:4][C:3](C(N2CCCC(C(OCC)=O)C2)=O)=[CH:2]1.[C:19]([N:27]1[CH2:32][CH2:31][CH2:30][CH:29]([C:33]([OH:35])=[O:34])[CH2:28]1)(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.C(O)CCC>>[C:19]([N:27]1[CH2:32][CH2:31][CH2:30][CH:29]([C:33]([O:35][CH2:2][CH2:3][CH2:4][CH3:5])=[O:34])[CH2:28]1)(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Komponenten

4

Edukt 3

HCID 2631-ButanolHCID 31364741-Benzoylpiperidine-3-carboxylic acidHCID 12114708Ethyl 1-(3-thiophenecarbonyl)-3-piperidinecarboxylate

Produkt 1

HCID 53869174n-Butyl 1-benzoyl-3-piperidinecarboxylate

Versuchsvorschrift

The reaction was run in the same manner as ethyl 1-(3-thiophenecarbonyl)-3-piperidinecarboxylate, starting with 1-benzoyl-3-piperidine carboxylic acid (500 mg; 2.1 mmol) and commercially available n-butanol (500 μl; 5.5 mmol). The crude product was distilled at 225° C./0.1 torr, giving n-butyl 1-benzoyl-3-piperidinecarboxylate (258.2 mg) as a light yellow oil. MS m/z (positive ion) 312 (M+Na+; 75), 290 (NH+; 100).

Aufarbeitung

  1. distillationThe crude product was distilled at 225° C./0.1 torr

Quellen und Nachweise

ORD-Eintrag
ord-0217d07fab2f45c7a9c830dcd14a8100
Quelldatensatz
uspto-grants-2003_12
Patentnummer
US06664271B1

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