3-Benzoylbenzoic acid → 3-Benzylbenzoic acid

HRID 433362Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 433362
[C:1]([C:9]1[CH:10]=[C:11]([CH:15]=[CH:16][CH:17]=1)[C:12]([OH:14])=[O:13])(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(OCC)(=O)C.OS(O)(=O)=O.CCCCCC.[Pd]>[CH2:1]([C:9]1[CH:10]=[C:11]([CH:15]=[CH:16][CH:17]=1)[C:12]([OH:14])=[O:13])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

6

Edukt 1

HCID 1013863-Benzoylbenzoic acid

Produkt 1

HCID 41245533-Benzylbenzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 23938PalladiumKatalysatorHCID 1118Sulfuric AcidLösungsmittelHCID 8058HexaneLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a Parr bottle containing 3-benzoylbenzoic acid (0.044 moles) (Aldrich) in 150 mL of ethyl acetate and 4.5 mL of concentrated H2SO4 was added 10 grams of 5% Pd/C. The mixture was hydrogenated on a Parr apparatus under hydrogen (45 psi) overnight. The reaction mixture was then filtered through Hyflo, washing with ethyl acetate. The filterate was dried over Na2SO4, filtered and concentrated to give an oil. The oil was slurried in hexane and the resulting white solid was collected by filtration to afford 3-benzylbenzoic acid, which was used without further purification.

Aufarbeitung

  1. filtrationThe reaction mixture was then filtered through Hyflo
  2. washwashing with ethyl acetate
  3. dry with materialThe filterate was dried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customto give an oil
  7. filtrationthe resulting white solid was collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-4ae460d23fe1452195ca3c49664f364d
Quelldatensatz
uspto-grants-2003_12
Patentnummer
US06667305B1

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