Bromine → 2-Bromo-1-(4-fluorophenyl)-2-(4-(methylsulfonyl)phenyl)ethanone

HRID 433919

Reaktionsgleichung

Reaktionsgleichung von HRID 433919
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:20])[CH2:9][C:10]2[CH:15]=[CH:14][C:13]([S:16]([CH3:19])(=[O:18])=[O:17])=[CH:12][CH:11]=2)=[CH:4][CH:3]=1.[Br:21]Br>C(Cl)(Cl)Cl.C(Cl)(Cl)(Cl)Cl>[Br:21][CH:9]([C:10]1[CH:15]=[CH:14][C:13]([S:16]([CH3:19])(=[O:17])=[O:18])=[CH:12][CH:11]=1)[C:8]([C:5]1[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=1)=[O:20]

Komponenten

5

Edukt 2

HCID 24408Bromine2×HCID 112433011-(4-Fluorophenyl)-2-(4-methylsulfonylphenyl)ethanone

Produkt 1

HCID 112340792-Bromo-1-(4-fluorophenyl)-2-(4-(methylsulfonyl)phenyl)ethanoneAusbeute 75,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 5943Carbon TetrachlorideLösungsmittel2×HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

A mixture of 1-(4-fluorophenyl)-2-(4-methylsulfonyl phenyl)ethanone (14.6 g, 50 mmol) in 210 mL of chloroform and 826 mL of CCl4. A solution of 8.0 g (50 mmol) of bromine in CCl4 was added dropwise to the mixture. When the loss of the bromine colour was complete, the organic layer was washed with 5% aqueous sodium bicarbonate solution and with brine. It was dried over anhydrous sodium sulfate. The drying agent was filtered, and the filtrate concentrated in vacuum to give 14.0 g (70%) of the desired product as a solid.

Aufarbeitung

  1. washthe organic layer was washed with 5% aqueous sodium bicarbonate solution and with brine
  2. dry with materialIt was dried over anhydrous sodium sulfate
  3. filtrationThe drying agent was filtered
  4. concentrationthe filtrate concentrated in vacuum

Quellen und Nachweise

ORD-Eintrag
ord-84880694e21f4168b30407757433a720
Quelldatensatz
uspto-grants-2003_12
Patentnummer
US06670365B1

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