Phenyl isocyanate → N-(4-pyridazinyl)-N'-phenylurea

HRID 434457

Reaktionsgleichung

Reaktionsgleichung von HRID 434457
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[N:4][CH:3]=1.[C:8]1([N:14]=[C:15]=[O:16])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>CC(C)=O>[N:5]1[CH:6]=[CH:7][C:2]([NH:1][C:15]([NH:14][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:16])=[CH:3][N:4]=1

Komponenten

4

Edukt 2

HCID 7672Phenyl isocyanateHCID 2984924-Aminopyridazine

Produkt 1

HCID 12893792N-(4-pyridazinyl)-N'-phenylurea

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

200 mg. of 4-aminopyridazine was suspended in 50 ml. of acetone. To the resulting suspension, 1.2 times the amount of phenyl isocyanate theoretically calculated was added and the mixture then reacted at room temperature overnight. The crystals formed were taken out by filtration. By recrystallization from an excess of methanol, N-(4-pyridazinyl)-N'-phenylurea was obtained (yield, greater than 80%); melting point higher than 250° C.

Aufarbeitung

  1. customthe mixture then reacted at room temperature overnight
  2. customThe crystals formed
  3. filtrationwere taken out by filtration
  4. customBy recrystallization from an excess of methanol

Quellen und Nachweise

ORD-Eintrag
ord-9e4ffc2c86184b5a96e1e505db8d9a70
Quelldatensatz
uspto-grants-1983_08
Patentnummer
US04397678

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