2-Methyl-2-butene → 5-ethyl-4-(trifluoromethyl)-1H-imidazole-2-carboxylic acid
Reaktionsgleichung
[CH2:1]([C:3]1[NH:7][C:6]([CH:8]=[O:9])=[N:5][C:4]=1[C:10]([F:13])([F:12])[F:11])[CH3:2].Cl([O-])=[O:15].[Na+].P([O-])(O)(O)=O.[Na+].CC(=CC)C>>[CH2:1]([C:3]1[NH:7][C:6]([C:8]([OH:15])=[O:9])=[N:5][C:4]=1[C:10]([F:12])([F:13])[F:11])[CH3:2]Komponenten
5
Versuchsvorschrift
The same operation as in Example (33c) was performed using 5-ethyl-4-(trifluoromethyl)-1H-imidazole-2-carbaldehyde obtained in Example (39d) (110 mg, 0.57 mmol), sodium chlorite (108 mg, 1.19 mmol), sodium dihydrogenphosphate (178 mg, 1.14 mmol) and 2-methyl-2-butene (0.3 mL, 2.84 mmol), to obtain 117.5 mg of the title compound as a white solid (99%).
Quellen und Nachweise
- ORD-Eintrag
- ord-9cd2a23896944e8e8f3051454bacca09
- Quelldatensatz
- uspto-grants-2013_09
- Patentnummer
- US08536197B2
Notizen zur Reaktion
Wird geladen…