Hydrochloric Acid → (E)-1-(4-hydroxyphenyl)-5-(4-morpholinyl)-1-penten-3-one hydrochloride

HRID 435112

Reaktionsgleichung

Reaktionsgleichung von HRID 435112
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[CH:9][C:10](=[O:12])[CH3:11])=[CH:4][CH:3]=1.[CH2:13]=O.[NH:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1.[ClH:21]>CC(C)=O.C(O)C>[ClH:21].[OH:1][C:2]1[CH:3]=[CH:4][C:5](/[CH:8]=[CH:9]/[C:10](=[O:12])[CH2:11][CH2:13][N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)=[CH:6][CH:7]=1

Komponenten

7

Edukt 4

HCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 8083MorpholineHCID 956483-Buten-2-one, 4-(4-hydroxyphenyl)-

Produkt 1

HCID 12842146(E)-1-(4-hydroxyphenyl)-5-(4-morpholinyl)-1-penten-3-one hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 180AcetoneLösungsmittelHCID 702EthanolLösungsmittel

Versuchsvorschrift

4.86 g (0.03 mole) of 4-(4-hydroxyphenyl)-3-buten-2-one, 1.2 g (0.04 mole) of paraformaldehyde and 2.6 g (0.03 mole) of morpholine is added to 60 ml of ethanol and 6 ml of concentrated HCl is added thereto. The mixture is heated at reflux temperature for 18 hours and then cooled to room temperature. The resultant mixture is diluted with acetone to a volume of 250 ml and subsequently chilled overnight. The insoluble material is filtered and recrystallized from a mixture of ethyl and methyl alcohols. The crystals are filtered and vacuum dried overnight, yielding (E)-1-(4-hydroxyphenyl)-5-(4-morpholinyl)-1-penten-3-one hydrochloride; m.p. 195°-196° C.

Aufarbeitung

  1. additionis added
  2. temperatureThe mixture is heated
  3. temperatureat reflux temperature for 18 hours
  4. filtrationThe insoluble material is filtered
  5. customrecrystallized from a mixture of ethyl and methyl alcohols
  6. filtrationThe crystals are filtered
  7. customvacuum dried overnight

Quellen und Nachweise

ORD-Eintrag
ord-bd8d2fed1b9b4ffd89e4cc1aacb584d9
Quelldatensatz
uspto-grants-1983_08
Patentnummer
US04400380

Verknüpfte Notizen

Wird geladen…