Bromine → Methyl 4-bromo-3-oxopentanoate

HRID 43517

Reaktionsgleichung

Reaktionsgleichung von HRID 43517
[O:1]=[C:2]([CH2:8][CH3:9])[CH2:3][C:4]([O:6][CH3:7])=[O:5].[Br:10]Br>C(Cl)(Cl)Cl>[Br:10][CH:8]([CH3:9])[C:2](=[O:1])[CH2:3][C:4]([O:6][CH3:7])=[O:5]

Komponenten

4

Edukt 2

HCID 24408BromineHCID 121699Methyl 3-oxovalerate

Produkt 1

HCID 9815681Methyl 4-bromo-3-oxopentanoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

Methyl 3-oxopentanoate (1 g, 7.68 mmol) was dissolved in chloroform (30 mL). Bromine (0.4 mL, 7.80 mmol) was added under ice-cooling and the mixture was stirred for 40 minutes. The reaction solution was washed with saturated aqueous sodium bicarbonate solution, dried over anhydrous sodium sulfate and then concentrated under reduced pressure. The resulting compound was used for the next reaction without purification.

Aufarbeitung

  1. temperaturecooling
  2. washThe reaction solution was washed with saturated aqueous sodium bicarbonate solution
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationconcentrated under reduced pressure
  5. customThe resulting compound was used for the next reaction without purification

Quellen und Nachweise

ORD-Eintrag
ord-eeb1d3c862ba4424958c3286cfe142e9
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08536197B2

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