Water → 2-Phenylthio-5-trifluoromethyl-phenylacetonitrile

HRID 435656Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 435656
[C-:1]#[N:2].[Na+].[C:4]1([S:10][C:11]2[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][C:12]=2[CH2:13]Cl)[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.O>CS(C)=O>[C:4]1([S:10][C:11]2[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][C:12]=2[CH2:13][C:1]#[N:2])[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 8929Sodium CyanideHCID 15619001HCID 15619001, Verbindung

Produkt 1

HCID 122239582-Phenylthio-5-trifluoromethyl-phenylacetonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel2×

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

11.2 g of sodium cyanide in 135 ml of dimethyl sulphoxide are warmed to 40° c and treated dropwise over a period of 10 minutes with a solution of 87 g of 2-(phenylthio)-5-trifluoromethyl-benzyl chloride in 72 ml of dimethyl sulphoxide. The mixture is stirred at 40° C for 9 hours, cooled to room temperature, treated with 200 ml of water and extracted with 200 ml of ether. The aqueous phase is then extracted twice with 100 ml of ether each time. The combined organic phases are now washed twice with 200 ml of water each time, dried over sodium sulphate and evaporated under reduced pressure. There is obtained 2-(phenylthio)-5-trifluoromethyl-phenylacetonitrile as a dark-red oil.

Aufarbeitung

  1. temperaturecooled to room temperature
  2. extractionextracted with 200 ml of ether
  3. extractionThe aqueous phase is then extracted twice with 100 ml of ether each time
  4. washThe combined organic phases are now washed twice with 200 ml of water each time
  5. dry with materialdried over sodium sulphate
  6. customevaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-156bfe3bd03f49fabfdfd57cc044565e
Quelldatensatz
uspto-grants-1977_02
Patentnummer
US04006145

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