Dichloromethane → HCID 21455283, Verbindung

HRID 436198Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 436198
C([O:8][C:9]1[CH:10]=[C:11]([C:15]2[N:26]=[C:18]3[C:19]4[C:24]([CH2:25][N:17]3[N:16]=2)=[CH:23][CH:22]=[CH:21][CH:20]=4)[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1.C(Cl)Cl>C(O)C.[Pd]>[OH:8][C:9]1[CH:10]=[C:11]([C:15]2[N:26]=[C:18]3[C:19]4[C:24]([CH2:25][N:17]3[N:16]=2)=[CH:23][CH:22]=[CH:21][CH:20]=4)[CH:12]=[CH:13][CH:14]=1

Komponenten

5

Edukt 2

HCID 6344DichloromethaneHCID 21455293HCID 21455293, Verbindung

Produkt 1

HCID 21455283HCID 21455283, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

2-(3-Benzyloxyphenyl)-5H-s-triazolo[5,1-a] isoindole (17 g) is suspended in 500 ml of ethanol and hydrogenated at atmospheric pressure and room temperature in the presence of 3 g of 10% Pd on charcoal. After addition of 500 ml of methylene chloride, the catalyst is filtered off and the solution is concentrated to dryness. The title product is purified by crystallization from dioxane. Yield 10.68 g (85.7%); m.p. 251-2°C.

Aufarbeitung

  1. filtrationthe catalyst is filtered off
  2. concentrationthe solution is concentrated to dryness
  3. customThe title product is purified by crystallization from dioxane

Quellen und Nachweise

ORD-Eintrag
ord-9a82c6f61a1e4f68bfca44da947ee874
Quelldatensatz
uspto-grants-1977_02
Patentnummer
US04007276

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