HCID 21430443, Verbindung → HCID 21430467, Verbindung

Reaktionsgleichung

[ClH:1].[CH2:2]([NH:5][S:6]([C:9]1[CH:10]=[C:11]([CH:15]=[CH:16][C:17]=1[N:18]1[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][CH2:19]1)[C:12]([OH:14])=[O:13])(=[O:8])=[O:7])[CH:3]=[CH2:4].[H][H]>O1CCCC1.[Pd]>[ClH:1].[CH3:24][N:21]1[CH2:22][CH2:23][N:18]([C:17]2[CH:16]=[CH:15][C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]=2[S:6](=[O:8])(=[O:7])[NH:5][CH2:2][CH2:3][CH3:4])[CH2:19][CH2:20]1

Komponenten

Versuchsvorschrift

37.6 Grams of 3-allylsulfamoyl-4-(4-methylpiperazine-1-yl)-benzoic acid-hydrochloride (0.1 mole), prepared according to Example 32, were dissolved in 0.3 l of tetrahydrofurane and were hydrogentated in the presence of palladium black at 30° C. and at 40 atmospheres until no more hydrogen was absorbed. Subsequently the catalyst was separated, the solution was evaporated, and the residue was recrystallized from water.