Sodium Carbonate → 1,3-Bis[4-(2-benzoylhydrazino)phenyl]thiourea

HRID 437288

Reaktionsgleichung

Reaktionsgleichung von HRID 437288
[C:1](=[O:4])([O-])[O-].[Na+].[Na+].C(CS[C:12](=[S:18])SCC(O)=O)(O)=O.[C:19]([NH:27][NH:28][C:29]1[CH:34]=[CH:33][C:32]([NH2:35])=[CH:31][CH:30]=1)(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>O.C(O)C>[C:19]([NH:27][NH:28][C:29]1[CH:30]=[CH:31][C:32]([NH:35][C:12]([NH:35][C:32]2[CH:31]=[CH:30][C:29]([NH:28][NH:27][C:1](=[O:4])[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[CH:34][CH:33]=2)=[S:18])=[CH:33][CH:34]=1)(=[O:26])[C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

Komponenten

6

Edukt 3

HCID 10340Sodium CarbonateHCID 806183,5-Dithia-4-thioxo-1,7-heptanedioic acidHCID 20508846N'-(4-Aminophenyl)benzohydrazide

Produkt 1

HCID 214278171,3-Bis[4-(2-benzoylhydrazino)phenyl]thiourea

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

Sodium carbonate (4.65 g, 0.044 mole) was dissolved in a solvent mixture of water (95 ml) and ethanol (30 ml). Bis(carboxymethyl)trithiocarbonate (2.5 g, 0.011 mole) was added portionwise. Vigorous stirring of the reaction mixture was maintained until all solid was dissolved. It was then heated to 80°-85° C and 1-benzoyl-2-(4-aminophenyl)hydrazine (5.0 g, 0.022 mole) was added in one portion. Stirring and heating were maintained for one and one-half hour and the reaction mixture was then chilled. The solid was removed by filtration, washed and dried. Yield 2.05 g (37%), m.p. 185°-187° C.

Aufarbeitung

  1. temperaturewas maintained until all solid
  2. dissolutionwas dissolved
  3. temperatureIt was then heated to 80°-85° C
  4. stirringStirring
  5. temperatureheating
  6. temperaturewere maintained for one and one-half hour
  7. temperaturethe reaction mixture was then chilled
  8. customThe solid was removed by filtration
  9. washwashed
  10. customdried

Quellen und Nachweise

ORD-Eintrag
ord-32d4633a0c2142058be403c8811ea4c0
Quelldatensatz
uspto-grants-1977_06
Patentnummer
US04030925

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