Dimethyl Sulfoxide → 2-(4-Methyl-phenoxy)-5-methyl-phenylacetonitrile

HRID 437804Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 437804
Cl[CH2:2][C:3]1[CH:4]=[C:5]([CH3:17])[CH:6]=[CH:7][C:8]=1[O:9][C:10]1[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][CH:11]=1.CS(C)=O.[C-:22]#[N:23].[Na+]>O>[CH3:16][C:13]1[CH:14]=[CH:15][C:10]([O:9][C:8]2[CH:7]=[CH:6][C:5]([CH3:17])=[CH:4][C:3]=2[CH2:2][C:22]#[N:23])=[CH:11][CH:12]=1

Komponenten

5

Edukt 3

HCID 679Dimethyl Sulfoxide2×HCID 8929Sodium CyanideHCID 227679253-Chloromethyl-4-(4-methyl-phenoxy)-toluene

Produkt 1

HCID 543008532-(4-Methyl-phenoxy)-5-methyl-phenylacetonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
36 °C

Versuchsvorschrift

A solution of 108 g. of 3-chloromethyl-4-(4-methyl-phenoxy)-toluene in 70 ml. of dimethylsulfoxide is added dropwise at 20°-25° C. to a suspension of 23 g. of sodium cyanide in 35 ml. of dimethylsulfoxide. The mixture is subsequently stirred for 4 hours at 36° C., then diluted with 1 liter of water and extracted three times with benzene. The benzene extracts are washed three times with water, then dried over sodium sulfate and evaporated in vacuo, and there is obtained crude 2-(4-methyl-phenoxy)-5-methyl-phenylacetonitrile as a brown oil.

Aufarbeitung

  1. extractionextracted three times with benzene
  2. washThe benzene extracts are washed three times with water
  3. dry with materialdried over sodium sulfate
  4. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-516555ed50fe41a19170c776b9a5d3d3
Quelldatensatz
uspto-grants-1977_06
Patentnummer
US04032525

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