Hydrochloric Acid → 1-(4-Methoxyphenyl)cyclobutane-1-carboxylic acid

HRID 440532Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 440532
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([C:13]#N)[CH2:12][CH2:11][CH2:10]2)=[CH:5][CH:4]=1.[OH-:15].[K+].C(O)COCCO.Cl.[OH2:25]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([C:13]([OH:25])=[O:15])[CH2:12][CH2:11][CH2:10]2)=[CH:5][CH:4]=1

Komponenten

6

Edukt 5

HCID 313Hydrochloric AcidHCID 962WaterHCID 8117Diethylene GlycolHCID 14797Potassium HydroxideHCID 219020981-(4-Methoxyphenyl)cyclobutane-1-carbonitrile

Produkt 1

HCID 167699461-(4-Methoxyphenyl)cyclobutane-1-carboxylic acid

Versuchsvorschrift

A mixture of 1-(4-methoxyphenyl)cyclobutane carbonitrile (41 g), potassium hydroxide (20 g) and diethylene glycol (160 ml) was heated under reflux for 3.5 hours. The mixture was added to water, acidified with dilute hydrochloric acid and extracted with ether. The extract yielded 1-(4-methoxyphenyl)cyclobutane carboxylic acid.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for 3.5 hours
  3. extractionextracted with ether

Quellen und Nachweise

ORD-Eintrag
ord-b88dba37139741bea049d5b66a6142bf
Quelldatensatz
uspto-grants-1996_05
Patentnummer
US05519034

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