Hydrochloric Acid → 2-Methyl-5-(4-chlorobenzylidene)-cyclopentanone

HRID 440568Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 440568
[OH-].[Na+].[Cl:3][C:4]1[CH:21]=[CH:20][C:7]([CH:8]=[C:9]2[CH2:13][CH2:12][C:11](C)([C:14](OC)=O)[C:10]2=[O:19])=[CH:6][CH:5]=1.Cl>O>[Cl:3][C:4]1[CH:5]=[CH:6][C:7]([CH:8]=[C:9]2[CH2:13][CH2:12][CH:11]([CH3:14])[C:10]2=[O:19])=[CH:20][CH:21]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 67742476Methyl 3-(4-chlorobenzylidene)-1-methyl-2-oxocylopentanecarboxylate

Produkt 1

HCID 537529512-Methyl-5-(4-chlorobenzylidene)-cyclopentanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

A solution of 12 g of sodium hydroxide in 20 ml of water was added to 10 g of methyl 3-(4-chloro-benzylidene)-1-methyl-2-oxocylopentanecarboxylate (I-1) (prepared in Example 1). The mixture was stirred for 2 hours at 80° C. The reaction mixture was poured into 10% aqueous solution of hydrochloric acid and extracted with ethyl acetate. The organic layer was washed with water and dried over anhydrous sodium sulfate. The solvent was evaporated to obtain 4.1 g of an oily matter (yield, 51.8%).

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with water
  3. dry with materialdried over anhydrous sodium sulfate
  4. customThe solvent was evaporated
  5. customto obtain
  6. custom4.1 g of an oily matter (yield, 51.8%)

Quellen und Nachweise

ORD-Eintrag
ord-23395d6cb26a41428953a5a61b9eee6c
Quelldatensatz
uspto-grants-1996_05
Patentnummer
US05519160

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