Water → HCID 15337396, Verbindung

HRID 441157

Reaktionsgleichung

Reaktionsgleichung von HRID 441157
[CH3:1][S:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11](=[O:18])[C:10]=2[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:5][CH:4]=1.C1C=C(C([O-])=[O:32])C(C(O[O-])=O)=CC=1.[Mg+2].[OH2:39].C([O-])(O)=O.[Na+]>C(Cl)Cl.CO.CCOC(C)=O>[CH3:1][S:2]([C:3]1[CH:4]=[CH:5][C:6]([C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11](=[O:18])[C:10]=2[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:7][CH:8]=1)(=[O:32])=[O:39]

Komponenten

8

Edukt 4

HCID 962WaterHCID 516892Sodium BicarbonateHCID 10130449Monoperoxyphthalic Acid Magnesium SaltHCID 15337399HCID 15337399, Verbindung

Produkt 1

HCID 15337396HCID 15337396, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 887MethanolLösungsmittelHCID 6344DichloromethaneLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To an ice cold solution of the compound from Step 1 (525 mg, 1.6 mmol) in CH2Cl2 (16 mL) and MeOH (1.6 mL) was added MMPP (1.09 g, tech. 80%, 1.76 mmol). The resulting suspension was stirred at r.t. for 3 hrs. The reaction was diluted with EtOAc and a 1:1 mixture of H2O and saturated aqueous NaHCO3 and extracted. The aqueous layer was extracted one more time with EtOAc. The combined organic extracts were dried over MgSO4 and concentrated to dryness. The crude product was purified first by flash chromatography, eluted with EtOAc in hexane 35%, and then crystallized from EtOAc/Hexane (1:1, 20 mL) to give the title compound as a bright orange solid.

Aufarbeitung

  1. extractionextracted
  2. extractionThe aqueous layer was extracted one more time with EtOAc
  3. dry with materialThe combined organic extracts were dried over MgSO4
  4. concentrationconcentrated to dryness
  5. customThe crude product was purified first by flash chromatography
  6. washeluted with EtOAc in hexane 35%
  7. customcrystallized from EtOAc/Hexane (1:1, 20 mL)

Quellen und Nachweise

ORD-Eintrag
ord-412b7d6753d94ec6b6ce90b88f8f6fd9
Quelldatensatz
uspto-grants-1996_05
Patentnummer
US05521213

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