Carbon Dioxide → 2-(2,3-Dihydro-1,4-benzodioxin-2-yl)-1-(4-hydroxy-4-phenylpiperidin-1-yl)ethan-1-one

HRID 441425

Reaktionsgleichung

Reaktionsgleichung von HRID 441425
[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[O:4][CH2:3][CH:2]1[CH2:11][C:12]([OH:14])=O.C(=O)=O.[OH:18][C:19]1([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>O1CCCC1>[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[O:4][CH2:3][CH:2]1[CH2:11][C:12]([N:22]1[CH2:23][CH2:24][C:19]([OH:18])([C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)[CH2:20][CH2:21]1)=[O:14]

Komponenten

5

Edukt 3

HCID 280Carbon DioxideHCID 963874-Phenylpiperidin-4-olHCID 2675342,3-Dihydro-1,4-benzodioxin-2-acetic acid

Produkt 1

HCID 213319822-(2,3-Dihydro-1,4-benzodioxin-2-yl)-1-(4-hydroxy-4-phenylpiperidin-1-yl)ethan-1-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To the stirred solution of 11.64 g of 2-(1,4-benzodioxan-2-yl)-acetic acid in 60 ml of tetrahydrofuran is added 12 g of 1,1-carbonyldiimidazole. After the evolution of carbon dioxide has ceased, 10.6 g of 4-hydroxy-4-phenylpiperidine are added and the mixture stirred overnight at room temperature. It is evaporated, the residue taken up in ethyl acetate, the solution washed with water, N hydrochloric acid and water, dried and evaporated, to yield the 1-[2-(1,4-benzodioxan-2-yl)-acetyl]-4-hydroxy-4-phenylpiperidine.

Aufarbeitung

  1. customIt is evaporated
  2. washthe solution washed with water, N hydrochloric acid and water
  3. customdried
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-08551823fb5945eea5effcb568540a25
Quelldatensatz
uspto-grants-1977_08
Patentnummer
US04039676

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