Sodium Hydroxide → (S)-2-((S)-2-tert-Butoxycarbonylamino-3,3-dimethyl-butyrylamino)-propionic acid

HRID 44146

Reaktionsgleichung

Reaktionsgleichung von HRID 44146
[C:1]([O:5][C:6]([NH:8][C@@H:9]([C:13]([CH3:16])([CH3:15])[CH3:14])[C:10]([OH:12])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH-:17].[Na+]>C1COCC1.O>[C:1]([O:5][C:6]([NH:8][C@@H:9]([C:13]([CH3:16])([CH3:15])[CH3:14])[C:10]([NH:8][C@@H:9]([CH3:13])[C:10]([OH:12])=[O:17])=[O:12])=[O:7])([CH3:2])([CH3:3])[CH3:4]

Komponenten

5

Edukt 2

HCID 14798Sodium HydroxideHCID 2734668(S)-2-((tert-Butoxycarbonyl)amino)-3,3-dimethylbutanoic acid

Produkt 1

HCID 86674881(S)-2-((S)-2-tert-Butoxycarbonylamino-3,3-dimethyl-butyrylamino)-propionic acidAusbeute 191,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of (S)-2-(tert-butoxycarbonylamino)-3,3-dimethylbutanoic acid (18) (6.5 g, 19.7 mmol) in THF (30 mL) was added NaOH (1.7 g, 43.8 mmol) in H2O (60 mL) and the reaction mixture stirred at ambient temperature for 16 h. THF was subsequently removed in vacuo and the aqueous phase washed with EtOAc (50 mL). The aqueous phase was then adjusted to pH ˜2 by addition of 1M HCl and extracted with EtOAc (3×50 mL). The organics were combined dried over MgSO4 and evaporated to give the desired compound (20) as a white solid (5.7 g, 95%); AnalpH2_MeOH; Rt 2.61 min; m/z 303 (MH+); white solid

Aufarbeitung

  1. customTHF was subsequently removed in vacuo
  2. washthe aqueous phase washed with EtOAc (50 mL)
  3. additionThe aqueous phase was then adjusted to pH ˜2 by addition of 1M HCl
  4. extractionextracted with EtOAc (3×50 mL)
  5. dry with materialThe organics were combined dried over MgSO4
  6. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-8538f27e322f45068c5ac77bf9d37850
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08541363B2

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