Sodium Hydroxide → Drometrizole

HRID 441516

Reaktionsgleichung

Reaktionsgleichung von HRID 441516
[OH:1][C:2]1[C:7](C(CC)(C)C)=[CH:6][C:5]([C:13](CC)(C)C)=[CH:4][C:3]=1[N:18]=[N:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[N+:26]([O-])=O.OC1C=CC(C)=CC=1N=NC1C=CC=CC=1[N+]([O-])=O.[OH-].[Na+].[N+](C1C=CC=CC=1N=NC1C=CC=CC=1)([O-])=O>>[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:13])=[CH:4][C:3]=1[N:18]1[N:19]=[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]2=[N:26]1

Komponenten

5

Edukt 4

HCID 14798Sodium HydroxideHCID 740294-Methyl-2-[2-(2-nitrophenyl)diazenyl]phenolHCID 1041112-Nitro-2'-hydroxy-3',5'-bis(tert-amyl)azobenzeneHCID 142206Diazene, (nitrophenyl)phenyl-, (E)-

Produkt 1

HCID 17113Drometrizole

Versuchsvorschrift

When in Example 1, the 2'-hydroxy-3',5'-di-tert-amyl-2-nitroazobenzene was replaced by an equivalent amount of 2'-hydroxy-5'-methyl-2-nitroazobenzene and the mole ratio of sodium hydroxide to o-nitroazobenzene intermediate was increased from 0.42/1 to 1.26/1, the reaction went rapidly to yield the product 2-(2-hydroxy-5-methylphenyl)-2H-benzotriazole.

Quellen und Nachweise

ORD-Eintrag
ord-51913da19f294f22b2c30d29c6a754fb
Quelldatensatz
uspto-grants-1977_08
Patentnummer
US04041044

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