2,3-Dihydroxybutanedioic Acid → 3-Methyl-5,6,7,8-tetrahydroquinoline-8-thiocarboxamide tartrate

HRID 442148Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 442148
[CH3:1][C:2]1[CH:3]=[N:4][C:5]2[CH:6]([C:12](=[S:14])[NH2:13])[CH2:7][CH2:8][CH2:9][C:10]=2[CH:11]=1.[C:15]([OH:24])(=[O:23])[CH:16]([CH:18]([C:20]([OH:22])=[O:21])[OH:19])[OH:17]>C(O)(C)C>[C:20]([CH:18]([CH:16]([C:15]([OH:24])=[O:23])[OH:17])[OH:19])([OH:22])=[O:21].[CH3:1][C:2]1[CH:3]=[N:4][C:5]2[CH:6]([C:12](=[S:14])[NH2:13])[CH2:7][CH2:8][CH2:9][C:10]=2[CH:11]=1

Komponenten

4

Edukt 2

HCID 8752,3-Dihydroxybutanedioic AcidHCID 30039215,6,7,8-Tetrahydro-3-methyl-8-quinolinecarbothioamide

Produkt 1

HCID 203583983-Methyl-5,6,7,8-tetrahydroquinoline-8-thiocarboxamide tartrate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel2×

Versuchsvorschrift

To a solution of 3-methyl-5,6,7,8-tetrahydroquinoline-8-thiocarboxamide (13 g.) in hot isopropylalcohol (130 ml.) was added a solution of 9.5 g. tartaric acid in hot isopropylalcohol (65 ml.). The solution was filtered and allowed to cool. The precipitated crystals of the tartrate were removed by filtration, washed with a little cold isopropyl alcohol and dried. Yield 10.2g.m.p.158°-160° C. Found: C,50.56% H, 5.67%; N, 7.90%. Calc. for C15H20N2O6S : C, 50.55%; H, 5.65%; N, 7.86%.

Aufarbeitung

  1. filtrationThe solution was filtered
  2. temperatureto cool
  3. customThe precipitated crystals of the tartrate were removed by filtration
  4. washwashed with a little cold isopropyl alcohol
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-056cf76d45ef42bca6984471f419a091
Quelldatensatz
uspto-grants-1977_08
Patentnummer
US04044138

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