Ethyl oxamate → HCID 135705331, Verbindung

HRID 442213Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 442213
[NH2:1][C:2]1[C:11]([C:12]([NH2:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[C:15](OCC)(=O)[C:16]([NH2:18])=[O:17].C[O-].[Na+]>C(O)CO>[N:1]1[C:2]2=[N:3][C:4]3[C:9]([CH:10]=[C:11]2[C:12](=[O:13])[NH:14][C:15]=1[C:16]([NH2:18])=[O:17])=[CH:8][CH:7]=[CH:6][CH:5]=3

Komponenten

5

Edukt 3

HCID 69238Ethyl oxamateHCID 52002282-Amino-3-quinolinecarboxamideHCID 10942334Sodium Methoxide

Produkt 1

HCID 135705331HCID 135705331, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 174Ethylene GlycolLösungsmittel

Reaktionsbedingungen

Temperatur
170 °C

Versuchsvorschrift

A mixture of 2-aminoquinoline-3-carboxamide (2.0 g., 1.15 millimoles) ethyl oxamate (2.71 g., 23.1 millimoles), ethylene glycol (10 ml.) and sodium methoxide (10 mg.) is heated at 170° C. for 1 hour. The product is precipitated by slow addition of ice cold methanol (50 ml.) to the hot reaction mixture followed by chilling in an ice bath. It is filtered off, washed with cold methanol and dried in vacuo. Yield = 0.768 g. (28%). M.P. 320° C.

Aufarbeitung

  1. customThe product is precipitated by slow addition of ice cold methanol (50 ml.) to the hot reaction mixture
  2. temperatureby chilling in an ice bath
  3. filtrationIt is filtered off
  4. washwashed with cold methanol
  5. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-55ac4ce680434f528859486b19e42471
Quelldatensatz
uspto-grants-1977_08
Patentnummer
US04044134

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