Bromine → N-[4-(Bromoacetyl)phenyl]-N'-tert.-butylsulfamide

Reaktionsgleichung

[C:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][S:11]([NH:14][C:15]([CH3:18])([CH3:17])[CH3:16])(=[O:13])=[O:12])=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[Br:19]Br>BrBr.O1CCOCC1>[Br:19][CH2:2][C:1]([C:4]1[CH:5]=[CH:6][C:7]([NH:10][S:11]([NH:14][C:15]([CH3:18])([CH3:17])[CH3:16])(=[O:13])=[O:12])=[CH:8][CH:9]=1)=[O:3]

Komponenten

Versuchsvorschrift

A few drops of bromine (from a total of 10.3 g., 0.064 mole) is added to N-(4-acetylphenyl)-N'-tert.-butylsulfamide (17.3 g., 0.064 mole) in dioxane (200 ml.) solution at 15° C. and the solution is stirred until the color is discharged. The remainder of the bromine is added during 5 min. and the solution is stirred for an additional 10 min. thereafter. The solution is concentrated in vacuo and the residue triturated with isopropyl ether to give 20.7 g. (92%) of intermediate, recrystallized from isopropanol, m.p. 160.5°-161° C. (dec.)