Benzyl chloroformate → Carbamic acid, (6-hydroxyhexyl)-, phenylmethyl ester

HRID 442625

Reaktionsgleichung

Reaktionsgleichung von HRID 442625
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][OH:8].C(=O)([O-])[O-].[K+].[K+].[CH2:15]([O:22][C:23](Cl)=[O:24])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>O.ClCCl>[C:23]([NH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][OH:8])([O:22][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:24]

Komponenten

6

Edukt 3

HCID 10387Benzyl chloroformateHCID 11430Potassium CarbonateHCID 199606-Amino-1-hexanol

Produkt 1

HCID 4184071Carbamic acid, (6-hydroxyhexyl)-, phenylmethyl ester

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

6-Aminohexan-1-ol (11.7 g, 100 mmol) and potassium carbonate (16.58 g, 120 mmol) were dissolved in 100 mL water and 70 mL dichloromethane. Benzylchloroformate (14.27 mL, 100 mmol) was added dropwise over 30 minutes at a temperature of 25°-30° C. The resulting mixture stood overnight, then the dichloromethane layer was separated, washed with water (3×200 mL), 2N HCl (3×50 mL) and finally with water (3×100 mL), dried, and evaporated to give a white solid. The solid was recrystallized in hexane-ethylacetate (8:2) to give a solid, which was collected and dried under vacuum at room temperature. Yield: 23 g (91%).

Aufarbeitung

  1. customthe dichloromethane layer was separated
  2. washwashed with water (3×200 mL), 2N HCl (3×50 mL) and finally with water (3×100 mL)
  3. customdried
  4. customevaporated
  5. customto give a white solid
  6. customThe solid was recrystallized in hexane-ethylacetate (8:2)
  7. customto give a solid, which
  8. customwas collected
  9. customdried under vacuum at room temperature

Quellen und Nachweise

ORD-Eintrag
ord-8d199f257e1348d3a34d4ebea270c7bd
Quelldatensatz
uspto-grants-1999_04
Patentnummer
US05891862

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