Prisotinol → 3-Pyridinol, 6-[2-[(1-methylethyl)amino]propyl]-, (2E)-2-butenedioate (1:1) (salt)
Reaktionsgleichung
[CH:1]([NH:4][CH:5]([CH3:14])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][N:8]=1)([CH3:3])[CH3:2].[C:15]([OH:22])(=[O:21])/[CH:16]=[CH:17]/[C:18]([OH:20])=[O:19]>O>[C:15]([OH:22])(=[O:21])/[CH:16]=[CH:17]/[C:18]([OH:20])=[O:19].[CH:1]([NH:4][CH:5]([CH3:14])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][N:8]=1)([CH3:3])[CH3:2]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To the suspension of 116 g of 2-(2-isopropylaminopropyl)-5-pyridinol and 310 ml of water, 65 g of fumaric acid are added while stirring at 70° under nitrogen. The resulting clear solution is stirred at 20° overnight, the precipitate formed filtered off and washed 3 times with 15 ml of cold water each. 873 g thereof (from several batches) are dissolved in 2,100 ml of water at 70°, the solution filtered hot and the filtrate stirred at room temperature under nitrogen for 2 days. The resulting suspension is filtered and the residue washed twice with 250 ml of cold water each, to yield the 2-(2-isopropylaminopropyl)-5-pyridinol monofumarate melting at 180°-183° with decomposition.