Hydrochloric Acid → H-(D)Ala-Gly-OBzl.hydrochloride

HRID 443917

Reaktionsgleichung

Reaktionsgleichung von HRID 443917
[NH:1](C(OC(C)(C)C)=O)[C@@H:2]([C:4]([NH:6][CH2:7][C:8]([O:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:9])=[O:5])[CH3:3].[ClH:25].CCOCC>O1CCOCC1>[NH2:1][C@@H:2]([C:4]([NH:6][CH2:7][C:8]([O:10][CH2:11][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)=[O:9])=[O:5])[CH3:3].[ClH:25]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 15567200Boc-(D)Ala-Gly-OBzl

Produkt 1

HCID 131712174H-(D)Ala-Gly-OBzl.hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

3.4 g of Boc-(D)Ala-Gly-OBzl are dissolved in 50 ml of dioxane containing HCl and left to stand for one hour. The volume of the solution is reduced under vacuum and an excess of ether added. The precipitated salt is filtered off, dried and used as such for the coupling reaction.

Aufarbeitung

  1. waitleft
  2. filtrationThe precipitated salt is filtered off
  3. customdried
  4. customsuch for the coupling reaction

Quellen und Nachweise

ORD-Eintrag
ord-bde701a623bf43e4a1e85e704975ba84
Quelldatensatz
uspto-grants-1981_04
Patentnummer
US04261888

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