Dimethylamine → 2-(2-Hydroxy-5-cyanophenyl)-2-methyl N,N-dimethyl-propanoamide

HRID 444092Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 444092
[C:1]([C:3]1[CH:4]=[CH:5][C:6]2[O:10][C:9](=[O:11])[C:8]([CH3:13])([CH3:12])[C:7]=2[CH:14]=1)#[N:2].[CH3:15][NH:16][CH3:17]>C(OCC)C.C(O)C>[OH:10][C:6]1[CH:5]=[CH:4][C:3]([C:1]#[N:2])=[CH:14][C:7]=1[C:8]([CH3:13])([CH3:12])[C:9]([N:16]([CH3:17])[CH3:15])=[O:11]

Komponenten

5

Edukt 2

HCID 674DimethylamineHCID 205362475-Cyano-2,3-dihydro-3,3-dimethylbenzofuran-2-one

Produkt 1

HCID 205362102-(2-Hydroxy-5-cyanophenyl)-2-methyl N,N-dimethyl-propanoamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

A suspension of 5-cyano-2,3-dihydro-3,3-dimethylbenzofuran-2-one (3.7 g), prepared as in Example 3, in diethyl ether (50 ml) was treated with a solution of dimethylamine in ethanol (8.6 ml of a 20.8% solution) portionwise with stirring at room temperature. The mixture was stirred for two hours, and the product was isolated by filtration, yield 4 g, mp 146°-148° C.

Aufarbeitung

  1. stirringThe mixture was stirred for two hours
  2. customthe product was isolated by filtration, yield 4 g, mp 146°-148° C.

Quellen und Nachweise

ORD-Eintrag
ord-3824eb102bb14d77a15bda92aa209d29
Quelldatensatz
uspto-grants-1981_04
Patentnummer
US04263037

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