Lithium Hydroxide → 6-[(4-chlorophenyl)sulfanyl]-3-pyridinylamine

HRID 444462Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 444462
Cl[C:2]1[N:7]=[CH:6][C:5]([N+:8]([O-])=O)=[CH:4][CH:3]=1.[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([SH:18])=[CH:14][CH:13]=1.[OH-].[Li+]>CN(C=O)C>[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([S:18][C:2]2[N:7]=[CH:6][C:5]([NH2:8])=[CH:4][CH:3]=2)=[CH:14][CH:13]=1

Komponenten

5

Edukt 3

HCID 3939Lithium HydroxideHCID 7815p-ChlorothiophenolHCID 783082-Chloro-5-nitropyridine

Produkt 1

HCID 28001276-[(4-chlorophenyl)sulfanyl]-3-pyridinylamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

6-Chloro-3-nitropyridine (54.5 grams), 4-chlorothiophenol (50.0 grams), and lithium hydroxide (12.5 grams) were mixed in about 500 ml. of DMF and stirred overnight (about 18 hours) at room temperature. The reaction mixture was poured into ice-water, filtered, and the separated product washed three times with water and air dried, yield, 100 grams.

Aufarbeitung

  1. filtrationfiltered
  2. washthe separated product washed three times with water and air
  3. customdried
  4. customyield

Quellen und Nachweise

ORD-Eintrag
ord-f815efe19f0e4996899da64acd82ac39
Quelldatensatz
uspto-grants-1981_04
Patentnummer
US04264605

Notizen zur Reaktion

Wird geladen…