HCID 58134770, Verbindung → 1-Amino-1-(2-hydroxypropan-1-yl)cyclobutane

HRID 444780Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 444780
C([NH:8][C:9]1([CH2:13][CH:14]([OH:16])[CH3:15])[CH2:12][CH2:11][CH2:10]1)C1C=CC=CC=1>CCO.[Pd]>[NH2:8][C:9]1([CH2:13][CH:14]([OH:16])[CH3:15])[CH2:12][CH2:11][CH2:10]1

Komponenten

4

Edukt 1

HCID 58134770HCID 58134770, Verbindung

Produkt 1

HCID 552844011-Amino-1-(2-hydroxypropan-1-yl)cyclobutaneAusbeute 94,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

10% Pd—C (300 mg) was added to a solution of 1-[1-(benzylamino)cyclobutyl]-2-propanol (2.24 g, 10.2 mmol) in EtOH (50 mL) and the mixture was stirred under H2 gas (5 kgf/cm2) at room temperature for 10 hours. The mixture was filtered and the filtrate was concentrated in vacuo. Distillation of the residue gave the title compound as a pale yellow oil (1.24 g, 94%).

Aufarbeitung

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated in vacuo
  3. distillationDistillation of the residue

Quellen und Nachweise

ORD-Eintrag
ord-93fdf6017015460699d920979f2556f5
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08476261B2

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