Fumaric Acid → 4-(Dimethylamino)butyl 2-(4-((2-amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)methyl)phenyl)acetate difumaric acid salt

HRID 445059Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 445059
[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]/[C:4]([OH:6])=[O:5].[NH2:9][C:10]1[N:15]=[C:14]([CH3:16])[C:13]([CH2:17][C:18]2[CH:23]=[CH:22][C:21]([CH2:24][C:25]([O:27][CH2:28][CH2:29][CH2:30][CH2:31][N:32]([CH3:34])[CH3:33])=[O:26])=[CH:20][CH:19]=2)=[C:12]([NH:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])[N:11]=1>C(O)C.C(OC(C)=O)(C)C>[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]/[C:4]([OH:6])=[O:5].[C:1]([OH:8])(=[O:7])/[CH:2]=[CH:3]/[C:4]([OH:6])=[O:5].[NH2:9][C:10]1[N:15]=[C:14]([CH3:16])[C:13]([CH2:17][C:18]2[CH:19]=[CH:20][C:21]([CH2:24][C:25]([O:27][CH2:28][CH2:29][CH2:30][CH2:31][N:32]([CH3:33])[CH3:34])=[O:26])=[CH:22][CH:23]=2)=[C:12]([NH:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])[N:11]=1

Komponenten

5

Edukt 2

HCID 444972Fumaric AcidHCID 497799954-(Dimethylamino)butyl 2-[4-[[2-amino-4-methyl-6-(pentylamino)pyrimidin-5-yl]methyl]phenyl]acetate

Produkt 1

HCID 498393674-(Dimethylamino)butyl 2-(4-((2-amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)methyl)phenyl)acetate difumaric acid salt

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 7915Isopropyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
25 °C

Versuchsvorschrift

Fumaric acid (52.6 mg) was added to a stirred solution of 4-(dimethylamino)butyl 2-(4-((2-amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)methyl)phenyl)acetate (100.0 mg) in ethanol (0.6 ml). The solution was diluted with iPrOAc (0.6 ml) and stirred at 25° C. for 5 h. The resulting precipitate was collected by filtration, washed with combined solution with iPrOAc (0.6 ml) and ethanol (0.6 ml), and dried under reduced pressure to give the title compound as a white solid, 125.6 mg.

Aufarbeitung

  1. filtrationThe resulting precipitate was collected by filtration
  2. washwashed with combined solution with iPrOAc (0.6 ml) and ethanol (0.6 ml)
  3. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-fb36ec132ad94e27a3cbface8579a5fc
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08476288B2

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