2-Methyl-1-butanol → (s)-4-(6-Methyloctyloxy)benzonitrile

HRID 4451

Reaktionsgleichung

Reaktionsgleichung von HRID 4451
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][CH:4]=1)#[N:2].Br[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH:16]([CH3:19])[CH2:17][CH3:18].C(O)C(CC)C.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH3:19][C@@H:16]([CH2:17][CH3:18])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][O:9][C:6]1[CH:7]=[CH:8][C:3]([C:1]#[N:2])=[CH:4][CH:5]=1

Komponenten

6

Edukt 4

HCID 87232-Methyl-1-butanolHCID 11430Potassium CarbonateHCID 130194-CyanophenolHCID 135481051-Bromo-6-methyloctane

Produkt 1

HCID 54307675(s)-4-(6-Methyloctyloxy)benzonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

Add 5.75 g of 4-cyanophenol 10 g of 1 brom-6-methyl octane synthesized of available active amyl alcohol, 6.67 g of anhydrous potassium carbonate, 30 ml of N,N-dimethyl formamide into 100 ml four-mouth flask under nitrogen atmosphere, allow to react for 8 hours at 110° C. After the reaction, filter the insoluble matter, then extract ether. The organic layer is then washed with 5% NaOH, water and saturated salt water, then dried and evaporated to remove the ether. Then when the obtained oily matter is refined, 11.4 g of optical (s)-4-(6-methyloctyloxy)benzonitrile is obtained.

Aufarbeitung

  1. customto react for 8 hours at 110° C
  2. customAfter the reaction
  3. filtrationfilter the insoluble matter
  4. washThe organic layer is then washed with 5% NaOH, water and saturated salt water
  5. customdried
  6. customevaporated
  7. customto remove the ether

Quellen und Nachweise

ORD-Eintrag
ord-097ce1f06049442d8b63f92135cc032e
Quelldatensatz
uspto-grants-1988_02
Patentnummer
US04725688

Verknüpfte Notizen

Wird geladen…