Methanol → HCID 59536363, Verbindung

HRID 445303

Reaktionsgleichung

Reaktionsgleichung von HRID 445303
Cl.[F:2][C:3]1([F:10])[CH2:8][CH2:7][CH:6]([NH2:9])[CH2:5][CH2:4]1.Cl[C:12]([O:14][C:15]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=1)=[O:13].CCN(C(C)C)C(C)C.CO>C(Cl)Cl>[F:2][C:3]1([F:10])[CH2:8][CH2:7][CH:6]([NH:9][C:12](=[O:13])[O:14][C:15]2[CH:16]=[CH:17][C:18]([N+:21]([O-:23])=[O:22])=[CH:19][CH:20]=2)[CH2:5][CH2:4]1

Komponenten

6

Edukt 4

HCID 887MethanolHCID 81531DiisopropylethylamineHCID 821294-Nitrophenyl chloroformateHCID 231506694,4-Difluorocyclohexan-1-amine hydrochloride

Produkt 1

HCID 59536363HCID 59536363, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 4,4-difluorocyclohexanamine hydrochloride (Matrix scientific, 250 mg, 1.45 mmol) in DCM (5 mL) was added 4-nitrophenyl chloroformate (367 mg, 1.82 mmol) and DIEA (507 μl, 0.29 mmol). The resulting mixture was then stirred at RT for 16 h. Then, MeOH (2 mL) was added and the solvents were removed. The residue was purified by silica gel flash column chromatography (0%-100% EtOAc/hexane) to give the title compound as a yellow solid.

Aufarbeitung

  1. customthe solvents were removed
  2. customThe residue was purified by silica gel flash column chromatography (0%-100% EtOAc/hexane)

Quellen und Nachweise

ORD-Eintrag
ord-00c2f84f8c2b42dca18083329f211cb5
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08476297B2

Verknüpfte Notizen

Wird geladen…