benzyl N-[1-(2-fluoropentyl)piperidin-4-yl]carbamate → 1-(2-Fluoropentyl)piperidin-4-amine

HRID 445990Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 445990
[F:1][CH:2]([CH2:21][CH2:22][CH3:23])[CH2:3][N:4]1[CH2:9][CH2:8][CH:7]([NH:10]C(=O)OCC2C=CC=CC=2)[CH2:6][CH2:5]1>[Pd].CO>[F:1][CH:2]([CH2:21][CH2:22][CH3:23])[CH2:3][N:4]1[CH2:9][CH2:8][CH:7]([NH2:10])[CH2:6][CH2:5]1

Komponenten

4

Edukt 1

HCID 71293837benzyl N-[1-(2-fluoropentyl)piperidin-4-yl]carbamate

Produkt 1

HCID 866782421-(2-Fluoropentyl)piperidin-4-amineAusbeute 134,1 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysator2×HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of the chiral form (with a shorter retention time) of benzyl N-[1-(2-fluoropentyl)piperidin-4-yl]carbamate obtained in Example 1c (318 mg, 0.986 mmol), 10% Pd/C (100 mg) and methanol (7 ml) was stirred at room temperature for two hours under a hydrogen atmosphere. The atmosphere in the reaction vessel was replaced with nitrogen, 10% Pd/C was filtered off, and the solvent was distilled off to give the title compound (249 mg).

Aufarbeitung

  1. filtrationwas filtered off
  2. distillationthe solvent was distilled off

Quellen und Nachweise

ORD-Eintrag
ord-4f3e6e5ea5a74e1e9df4f15ff8a1b3f6
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08476301B2

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