Acetic Anhydride → (6-Methylpyridin-2-yl)methyl acetate

HRID 446814

Reaktionsgleichung

Reaktionsgleichung von HRID 446814
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[N+:3]=1[O-].[C:10]([O:13]C(=O)C)(=[O:12])[CH3:11]>>[C:10]([O:13][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[N:3]=1)(=[O:12])[CH3:11]

Komponenten

3

Edukt 2

HCID 7918Acetic AnhydrideHCID 140832,6-Dimethylpyridine N-oxide

Produkt 1

HCID 291137(6-Methylpyridin-2-yl)methyl acetate

Versuchsvorschrift

A solution of 2,6-dimethylpyridine 1-oxide (980 mg, 0.79 mmol) in acetic anhydride (5 mL) was refluxed for 1 h. The reaction mixture was then concentrated in vacuo to obtain the crude product. The crude material was purified via silica gel column chromatography using 20% ethyl acetate in hexanes to afford (6-methylpyridin-2-yl)methyl acetate (1.0 g) as a solid.

Aufarbeitung

  1. concentrationThe reaction mixture was then concentrated in vacuo
  2. customto obtain the crude product
  3. customThe crude material was purified via silica gel column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-52430759164042b49e3b56f82a9aa8ff
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08481534B2

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