Hydrochloric Acid → (6-Methylpyridin-2-yl)methanol hydrochloride

HRID 446815

Reaktionsgleichung

Reaktionsgleichung von HRID 446815
C([O:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH3:12])[N:7]=1)(=O)C.[ClH:13]>>[ClH:13].[CH3:12][C:8]1[N:7]=[C:6]([CH2:5][OH:4])[CH:11]=[CH:10][CH:9]=1

Komponenten

3

Edukt 2

HCID 313Hydrochloric AcidHCID 291137(6-Methylpyridin-2-yl)methyl acetate

Produkt 1

HCID 18413908(6-Methylpyridin-2-yl)methanol hydrochloride

Versuchsvorschrift

A solution of (6-methylpyridin-2-yl)methyl acetate (1.0 g) in concentrated HCl (3 mL) was refluxed for 1 h. The reaction mixture was then concentrated in vacuo to obtain the crude product. The crude material was azeotroped with toluene, and the residue obtained was filtered and dried in vacuo to afford (6-methylpyridin-2-yl)methanol hydrochloride (811 mg) as a solid.

Aufarbeitung

  1. concentrationThe reaction mixture was then concentrated in vacuo
  2. customto obtain the crude product
  3. customThe crude material was azeotroped with toluene
  4. customthe residue obtained
  5. filtrationwas filtered
  6. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-fbf72e3296044ccb8ffa6a04d73dd71d
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08481534B2

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