1,4-Dioxane → 1-Bromo-5-chloro-3-fluoro-2-isocyanatobenzene
Reaktionsgleichung
[Br:1][C:2]1[CH:8]=[C:7]([Cl:9])[CH:6]=[C:5]([F:10])[C:3]=1[NH2:4].Cl[C:12]([O:15]C(=O)OC(Cl)(Cl)Cl)(Cl)Cl.O1CCOCC1>CO>[Br:1][C:2]1[CH:8]=[C:7]([Cl:9])[CH:6]=[C:5]([F:10])[C:3]=1[N:4]=[C:12]=[O:15]Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 100 °C
Versuchsvorschrift
2-Bromo-4-chloro-6-fluoroaniline (5 mmol, 1.125 g), bis(trichloromethyl)carbonate (1.7 mmol, 0.50 g) and 1,4-dioxane (10 ml) were mixed together and the mixture was heated to 100° C. for 15 minutes; the mixture was then cooled to room temperature and it was filtered. The filtrate was concentrated to afford a mixture of products (2.2 g) containing the title compound, M++MeO=283 (LC-MS run in methanol).
Aufarbeitung
- temperaturethe mixture was then cooled to room temperature
- filtrationit was filtered
- concentrationThe filtrate was concentrated
- customto afford
Quellen und Nachweise
- ORD-Eintrag
- ord-88c1552265f04242a7076c8c56a419cf
- Quelldatensatz
- uspto-grants-2013_07
- Patentnummer
- US08481566B2
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