(R)-Methyl 2-((2-chloro-5-nitropyrimidin-4-yl)(cyclopentyl)amino)butanoate → (R)-methyl 2-((2-chloro-5-nitropyrimidin-4-yl)(isopropyl)amino)butanoate

HRID 44804

Reaktionsgleichung

Reaktionsgleichung von HRID 44804
[Cl:1][C:2]1[N:7]=[C:6]([N:8]([CH:16]2[CH2:20]CC[CH2:17]2)[C@H:9]([CH2:14][CH3:15])[C:10]([O:12][CH3:13])=[O:11])[C:5]([N+:21]([O-:23])=[O:22])=[CH:4][N:3]=1>CC(C)=O>[Cl:1][C:2]1[N:7]=[C:6]([N:8]([CH:16]([CH3:20])[CH3:17])[C@H:9]([CH2:14][CH3:15])[C:10]([O:12][CH3:13])=[O:11])[C:5]([N+:21]([O-:23])=[O:22])=[CH:4][N:3]=1

Komponenten

3

Edukt 1

HCID 58405447(R)-Methyl 2-((2-chloro-5-nitropyrimidin-4-yl)(cyclopentyl)amino)butanoate

Produkt 1

HCID 59815009(R)-methyl 2-((2-chloro-5-nitropyrimidin-4-yl)(isopropyl)amino)butanoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

Intermediate C-1 was prepared similarly to the synthetic methods used to prepare Intermediate A with the exception that acetone was used instead of cyclopentanone in the reductive amination step.

Aufarbeitung

  1. customIntermediate C-1 was prepared similarly to the synthetic methods

Quellen und Nachweise

ORD-Eintrag
ord-3fd893af0d6544c4821cd0d1f8d7b325
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08541418B2

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