HCID 519042, Verbindung → 1-(2-methylthiazol-5-yl)ethanone
Reaktionsgleichung
Br[C:2](=[C:6]([OH:8])[CH3:7])[C:3](=O)C.[C:9]([NH2:12])(=[S:11])[CH3:10]>CC(C)=O>[C:6]([C:2]1[S:11][C:9]([CH3:10])=[N:12][CH:3]=1)(=[O:8])[CH3:7]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a solution of the product of Example 151B (14.5 g, 88 mmol) in acetone (220 mL) was added thioacetamide (6.6 g, 88 mmol) and stirred overnight. The solid was filtered to give the title compound as the hydrogen bromide salt. 1H NMR (300 MHz, DMSO-d6) δ ppm 2.54 (s, 3 H) 2.71 (s, 3 H) 8.46 (s, 1 H). MS (DCI) m/z 142 (M+H)+.
Aufarbeitung
- filtrationThe solid was filtered
Quellen und Nachweise
- ORD-Eintrag
- ord-7ce2d9ad574a4beea8cdfbe631fa4f0f
- Quelldatensatz
- uspto-grants-2013_07
- Patentnummer
- US08481574B2
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