Nitrogen → 4-[5-Chloro-4-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-(methyl-o-tolyl-carbamoyl)-phenoxy]-butyric acid tert-butyl ester

HRID 448900Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 448900
[C:1]([O:5][C:6](=[O:38])[CH2:7][CH2:8][CH2:9][O:10][C:11]1[CH:16]=[C:15]([Cl:17])[C:14](B2OC(C)(C)C(C)(C)O2)=[CH:13][C:12]=1[C:27](=[O:37])[N:28]([CH3:36])[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[CH3:35])([CH3:4])([CH3:3])[CH3:2].Br[C:40]1[C:45]([C:46]#[N:47])=[CH:44][C:43]([C:48]([F:51])([F:50])[F:49])=[N:42][CH:41]=1.C([O-])([O-])=O.[Na+].[Na+].N#N>O1CCOCC1.O.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[C:1]([O:5][C:6](=[O:38])[CH2:7][CH2:8][CH2:9][O:10][C:11]1[CH:16]=[C:15]([Cl:17])[C:14]([C:40]2[CH:41]=[N:42][C:43]([C:48]([F:51])([F:50])[F:49])=[CH:44][C:45]=2[C:46]#[N:47])=[CH:13][C:12]=1[C:27](=[O:37])[N:28]([CH3:36])[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[CH3:35])([CH3:2])([CH3:4])[CH3:3]

Komponenten

8

Edukt 4

HCID 947NitrogenHCID 10340Sodium CarbonateHCID 569733155-Bromo-2-(trifluoromethyl)isonicotinonitrileHCID 686022774-[5-Chloro-2-(methyl-o-tolyl-carbamoyl)-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]-butyric acid tert-butyl ester

Produkt 1

HCID 686031324-[5-Chloro-4-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-(methyl-o-tolyl-carbamoyl)-phenoxy]-butyric acid tert-butyl esterAusbeute 99,6 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 178418397HCID 178418397, VerbindungKatalysatorHCID 962WaterLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

4-[5-Chloro-2-(methyl-o-tolyl-carbamoyl)-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]-butyric acid tert-butyl ester (444.0 mg, 0.8 mmol), 5-bromo-2-trifluoromethyl-isonicotinonitrile (171.0 mg, 0.7 mmol), Pd(Ph3P)4 (78.6 mg, 0.07 mmol), Na2CO3 (432.0 mg, 4.1 mmol) in dioxane (9 mL) and water (1 mL) was degassed with N2 for 5 min, sealed, and heated at 100° C. for 12 hrs. The mixture was then partitioned between ethyl acetate and water. The organic layer was washed with water and brine, dried over MgSO4 and filtered. Concentration and purification by TLC plates eluting with ethyl acetate in hexanes (2/3) and again with TLC plates eluting with acetonitrile/dichloromethane (1/9) gave 4-[5-chloro-4-(4-cyano-6-trifluoromethyl-pyridin-3-yl)-2-(methyl-o-tolyl-carbamoyl)-phenoxy]-butyric acid tert-butyl ester (410 mg). MS: 588.7 (M+H)+; tR=11.05 min (method 3).

Aufarbeitung

  1. customsealed
  2. customThe mixture was then partitioned between ethyl acetate and water
  3. washThe organic layer was washed with water and brine
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. concentrationConcentration and purification by TLC plates
  7. washeluting with ethyl acetate in hexanes (2/3) and again with TLC plates
  8. washeluting with acetonitrile/dichloromethane (1/9)

Quellen und Nachweise

ORD-Eintrag
ord-ce62bcc219f34b90958221d0ce22efe3
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08481738B2

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