Hydrazine hydrate (1:1) → HCID 178496609, Verbindung

HRID 449362Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 449362
[CH3:1][O:2][C@H:3]1[CH2:8][CH2:7][C@H:6]([N:9]2C(=O)C3C(=CC=CC=3)C2=O)[CH2:5][CH2:4]1.O.NN>C(O)C>[CH3:1][O:2][C@H:3]1[CH2:8][CH2:7][C@H:6]([NH2:9])[CH2:5][CH2:4]1

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 178496587HCID 178496587, Verbindung

Produkt 1

HCID 178496609HCID 178496609, VerbindungAusbeute 92,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 2-(trans-4-methoxycyclohexyl)-1H-isoindole-1,3(2H)-dione (0.27 g, 1.0 mmol), and hydrazine hydrate (63.3 uL, 0.00130 mol) in ethanol (2.0 mL) was heated at reflux for 1 h. After cooling, the solid was filtered off, and the filtrate was concentrated to yield the desired product (0.12 g, 89%).

Aufarbeitung

  1. temperaturewas heated
  2. temperatureat reflux for 1 h
  3. temperatureAfter cooling
  4. filtrationthe solid was filtered off
  5. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-161cf594e3d44384b010be0cbabbe67b
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08481732B2

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