Thionyl Chloride → 2,6-Dichloro-4-iodobenzoyl chloride

HRID 449917

Reaktionsgleichung

[Cl:1][C:2]1[CH:10]=[C:9]([I:11])[CH:8]=[C:7]([Cl:12])[C:3]=1[C:4](O)=[O:5].O=S(Cl)[Cl:15]>>[Cl:1][C:2]1[CH:10]=[C:9]([I:11])[CH:8]=[C:7]([Cl:12])[C:3]=1[C:4]([Cl:15])=[O:5]

Komponenten

Edukt 2

HCID 24386Thionyl Chloride

HCID 513418772,6-Dichloro-4-iodobenzoic acid

Produkt 1

HCID 866489582,6-Dichloro-4-iodobenzoyl chlorideAusbeute 100 %

Versuchsvorschrift

A solution of 2,6-dichloro-4-iodobenzoic acid (65 mg, 0.21 mmol) in SOCl2 (3 mL) was heated to reflux under nitrogen atmosphere overnight and then cooled to room temperature. The reaction was conentrated under reduced pressure to afford 2,6-dichloro-4-iodobenzoyl chloride (70 mg, 100% yield).

Aufarbeitung

temperatureto reflux under nitrogen atmosphere overnight

Quellen und Nachweise

ORD-Eintrag: ord-4d56422000ae457ca41ed97b75cb9c61
Quelldatensatz: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08486950B2

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