Oxalyl chloride → HCID 86621147, Verbindung

HRID 450028Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 450028
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[CH:7]=[C:8]2[N:13]([CH:14]=1)[CH:12]=[CH:11][CH:10]=[CH:9]2.[C:15](Cl)(=[O:19])[C:16]([Cl:18])=[O:17]>C1COCC1>[O:19]=[C:15]([C:14]1[N:13]2[C:8]([CH:9]=[CH:10][CH:11]=[CH:12]2)=[CH:7][C:6]=1[C:2]1[S:1][CH:5]=[CH:4][CH:3]=1)[C:16]([Cl:18])=[O:17]

Komponenten

4

Edukt 2

HCID 65578Oxalyl chlorideHCID 8530432-(Thiophen-2-yl)indolizine

Produkt 1

HCID 86621147HCID 86621147, VerbindungAusbeute 41,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To an ice-cold solution of 2-thiophen-2-yl-indolizine (0.5 g, 2.51 mmol) in THF (8 ml) was added oxalyl chloride (0.3 ml, 3.48 mmol). The reaction mixture was stirred at room temperature for 30 min. The solvent was evaporated under vacuum. The crude product was recrystallized from dichloromethane-hexane to give oxo-(2-thiophen-2-yl-indolizin-3-yl)-acetyl chloride (0.3 g, 41%).

Aufarbeitung

  1. customThe solvent was evaporated under vacuum
  2. customThe crude product was recrystallized from dichloromethane-hexane

Quellen und Nachweise

ORD-Eintrag
ord-9b40d8e8cbf541d5b5b5a4a43c84107b
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08486962B2

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