1-(Methylsulfonyl)-4-nitrobenzene → 4-(Methylsulfonyl)aniline

HRID 450051Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 450051
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-])=O)=[CH:7][CH:6]=1)(=[O:4])=[O:3]>CO.[Pd]>[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][CH:6]=1)(=[O:3])=[O:4]

Komponenten

4

Edukt 1

HCID 2584341-(Methylsulfonyl)-4-nitrobenzene

Produkt 1

HCID 796174-(Methylsulfonyl)anilineAusbeute 65 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 1-methanesulfonyl-4-nitro-benzene (500 mg, 2.48 mmol) in methanol (20 ml) was hydrogenated over 10% Pd—C (100 mg) at atmospheric pressure until no further gas uptake was observed. The reaction mixture was then filtered over celite and concentrated to give a residue, which was recrystallized from ethanol to yield 4-methanesulphonyl-phenylamine (276 mg, 65%) as solid.

Aufarbeitung

  1. filtrationThe reaction mixture was then filtered over celite and
  2. concentrationconcentrated
  3. customto give a residue, which
  4. customwas recrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-473679a4a6794f9a8bc325647e04b223
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08486962B2

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