2-Methoxy-5-nitropyrimidine → 2-Methoxypyrimidin-5-amine

HRID 450180

Reaktionsgleichung

Reaktionsgleichung von HRID 450180
[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([N+:9]([O-])=O)=[CH:5][N:4]=1>CO.[Pd]>[NH2:9][C:6]1[CH:5]=[N:4][C:3]([O:2][CH3:1])=[N:8][CH:7]=1

Komponenten

4

Edukt 1

HCID 3529002-Methoxy-5-nitropyrimidine

Produkt 1

HCID 3529042-Methoxypyrimidin-5-amineAusbeute 100 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

To 0.342 g (2.20 mmol) of the above nitro compound in MeOH (20 mL) was added 0.30 g of 10% Pd/C and the mixture was stirred under hydrogen (25 in/Hg) for 18 hrs. The reaction mixture was filtered through celite, and concentrated, to give 0.274 g (100% yield) of 5-amino-2-methoxypyrimidine as a colorless oil: 1H NMR (DMSO-d6) δ 8.05 (s, 2H), 3.94 (s, 3H); LCMS (APCI+) m/z: 126 (MH+, 100%).

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through celite
  2. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-baaf8f4908814131a2da245bbc3ce777
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08486939B2

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