Ammonium formate → 2-isopropoxypyridin-3-amine

Palladium hydroxide on carbon (20%, 0.076 g, 0.54 mmol) was added into a solution of 2-iso-propoxy-3-nitro-pyridine (1.97 g, 10.8 mmol) and ammonium formate (3.40 g, 54.0 mmol) in ethanol (100 mL) at ambient temperature. The solution was stirred for 2 hours at 90° C., cooled to ambient temperature, filtered through Celite and washed with MeOH. The filtrate was concentrated in vacuo and triturated from diethyl ether to yield brown oil which was used in the next step without further purification.

1. temperaturecooled to ambient temperature
2. filtrationfiltered through Celite
3. washwashed with MeOH
4. concentrationThe filtrate was concentrated in vacuo
5. customtriturated from diethyl ether
6. customto yield brown oil which
7. customwas used in the next step without further purification

ORD-Eintrag

ord-38b385b86d064a22905507dafa8eb245

Quelldatensatz

uspto-grants-2013_07

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08486953B2