Iodoethane → 3-Amino-5-chloro-2-(2-ethoxybenzoyl)-benzofuran

HRID 450840Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 450840
C(=O)([O-])[O-].[K+].[K+].[NH2:7][C:8]1[C:12]2[CH:13]=[C:14]([Cl:17])[CH:15]=[CH:16][C:11]=2[O:10][C:9]=1[C:18](=[O:26])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[OH:25].[CH2:27](I)[CH3:28]>CN(C=O)C.C(OCC)(=O)C>[NH2:7][C:8]1[C:12]2[CH:13]=[C:14]([Cl:17])[CH:15]=[CH:16][C:11]=2[O:10][C:9]=1[C:18](=[O:26])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[O:25][CH2:27][CH3:28]

Komponenten

6

Edukt 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 587073613-Amino-5-chloro-2-(2-hydroxybenzoyl)-benzofuran

Produkt 1

HCID 587073663-Amino-5-chloro-2-(2-ethoxybenzoyl)-benzofuran

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

A suspension of potassium carbonate (0.056 g, 0.4 mmol), 3-amino-5-chloro-2-(2-hydroxybenzoyl)-benzofuran (0.05 g, 0.4 mmol) and ethyl iodide (0.05 g, 0.34 mmol) in dry DMF is stirred at 60° C. for 2 h. The resulting mixture is diluted with ethyl acetate and washed with water. Drying over sodium sulfate, filtering, evaporating the solvent and purification of the residue by silicagel column chromatography yields the title compound, having a m.p. of 114-115° C.

Aufarbeitung

  1. washwashed with water
  2. dry with materialDrying over sodium sulfate
  3. filtrationfiltering
  4. customevaporating
  5. customthe solvent and purification of the residue by silicagel column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-16520b04eab941f4a7e5c566c4fd38a6
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08486996B2

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