3-Amino-5-chloro-2-(2-benzyloxybenzoyl)-benzofuran → 3-Amino-5-chloro-2-(2-hydroxybenzoyl)-benzofuran

HRID 450841Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 450841
[NH2:1][C:2]1[C:6]2[CH:7]=[C:8]([Cl:11])[CH:9]=[CH:10][C:5]=2[O:4][C:3]=1[C:12](=[O:27])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[O:19]CC1C=CC=CC=1>C(OCC)(=O)C.[Pd]>[NH2:1][C:2]1[C:6]2[CH:7]=[C:8]([Cl:11])[CH:9]=[CH:10][C:5]=2[O:4][C:3]=1[C:12](=[O:27])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1[OH:19]

Komponenten

4

Edukt 1

HCID 113034533-Amino-5-chloro-2-(2-benzyloxybenzoyl)-benzofuran

Produkt 1

HCID 587073613-Amino-5-chloro-2-(2-hydroxybenzoyl)-benzofuran

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

3-Amino-5-chloro-2-(2-benzyloxybenzoyl)-benzofuran (Example 1, 0.5 g, 1.3 mmol) in ethyl acetate (15 ml) is stirred at room temperature under an atmosphere of hydrogen in the presence of palladium on charcoal (0.025 g). After 3 h the mixture is filtered over Celite® and evaporated to dryness. Purification of the residue by chromatography yields the title compound, having a m.p. of 208-210° C.

Aufarbeitung

  1. filtrationAfter 3 h the mixture is filtered over Celite®
  2. customevaporated to dryness
  3. customPurification of the residue by chromatography

Quellen und Nachweise

ORD-Eintrag
ord-20fa3f48fa274d5ba5b0c9b6540c4feb
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08486996B2

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