5-Aminobenzimidazole → HCID 178450103, Verbindung

HRID 452062

Reaktionsgleichung

Reaktionsgleichung von HRID 452062
FC(F)(F)C([O-])=O.[NH2:8][C:9]1[CH:17]=[CH:16][C:12]2[N:13]=[CH:14][NH:15][C:11]=2[CH:10]=1.[CH2:18]([O:22][C:23]1[CH:30]=[CH:29][C:26]([CH:27]=O)=[CH:25][CH:24]=1)[CH2:19][CH2:20][CH3:21].[Si](C#N)(C)(C)C.[N:37]1([C:42](N2C=CN=C2)=[O:43])C=CN=[CH:38]1>>[NH:13]1[C:12]2[CH:16]=[CH:17][C:9]([N:8]3[CH:27]([C:26]4[CH:29]=[CH:30][C:23]([O:22][CH2:18][CH2:19][CH2:20][CH3:21])=[CH:24][CH:25]=4)[CH2:38][NH:37][C:42]3=[O:43])=[CH:10][C:11]=2[N:15]=[CH:14]1

Komponenten

6

Edukt 5

HCID 136235-AminobenzimidazoleHCID 682631,1'-CarbonyldiimidazoleHCID 798134-ButoxybenzaldehydeHCID 82115Trimethylsilyl cyanideHCID 84468Trifluoroacetate

Produkt 1

HCID 178450103HCID 178450103, Verbindung

Versuchsvorschrift

The compound was synthesized as trifluoroacetate salt starting from 5-aminobenzimidazole (0.585 g, 4.4 mmol), 4-butoxybenzaldehyde (0.691 mL, 4 mmol), TMSCN (0.5 mL, 4 mmol), PdC (10%, 0.02 g), TEA (1.03 mL, 7.4 mmol), di-(imidazol-1-yl)methanone (0.658, 4.06 mmol) as described in method 2. The product was purified by means of preparative HPLC.

Aufarbeitung

  1. customThe product was purified by means of preparative HPLC

Quellen und Nachweise

ORD-Eintrag
ord-f64d2906073f478486ba152c0c86acf2
Quelldatensatz
uspto-grants-2013_07
Patentnummer
US08486940B2

Verknüpfte Notizen

Wird geladen…